Pro-metastasis function of TGFβ mediated by the Smad pathway

被引：44

作者：

Kang, Yibin ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2006年 / 98卷 / 06期

关键词：

TGF beta; Smad; mouse model; tumor progression; metastasis;

D O I：

10.1002/jcb.20928

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transforming growth factor beta (TGF beta) signaling pathway plays a vital role in the development and homeostasis of normal tissues. Abnormal function of this pathway contributes to the initiation and progression of cancer. Smad proteins are key signal transducers of the TGF beta pathway and are essential for the growth suppression function of TGF beta. Smads are bona fide tumor suppressors whose mutation, deletion, and silencing are associated with many types of human cancer. However, the involvement and functional mechanism of Smad proteins in cancer metastasis are poorly defined. Recent studies using genetically modified cancer cells and mouse tumor models have provided concrete evidence for a Smad-dependent mechanism for metastasis promotion by TGF beta. Understanding the dual roles of Smad proteins in tumor initiation and progression has important implications for cancer therapeutics.

引用

页码：1380 / 1390

页数：11

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