Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients

被引：66

作者：

Debiaggi, Maurizia

Canducci, Filippo

Sampaolo, Michela

Marinozzi, Maria Chiara

Parea, Maurizio

Terulla, Cristina

Colombo, Anna Amelia

Alessandrino, Emilio Paolo

Bragotti, Letizia Zenone

Arghittu, Milena

Goglio, Antonio

Migliavacca, Roberta

Romero, Egidio

Clementi, Massimo

机构：

[1] Univ Pavia, Dipartimento Sci Morfol Eidol & Clin, Sez Microbiol, I-27100 Pavia, Italy

[2] Policlin San Matteo, Ist Ricovero & Cura Carattere Sci, Serv Anal Microbiol, Pavia, Italy

[3] Policlin San Matteo, Ist Ricovero & Cura Carattere Sci, Ctr Trapianti Midollo Osseo, Div Ematol, Pavia, Italy

[4] Ist Ricovero & Cura Carattere Sci San Raffaele, Lab Microbiol & Virol, Milan, Italy

[5] Univ Vita Salute San Raffaele, Milan, Italy

[6] Presidio Vizzolo Predabissi, Azienda Osped Melegnano, Bergamo, Italy

[7] Osped Riuniti Bergamo, Bergamo, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 04期

关键词：

D O I：

10.1086/505881

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection.

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收藏

页码：474 / 478

页数：5

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