Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

被引：41

作者：

Miyako, E ^{[1
]}

Maruyama, T ^{[1
]}

Kamiya, N ^{[1
]}

Goto, M ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Engn, Dept Appl Chem, Fukuoka 8128581, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 28期

关键词：

D O I：

10.1021/ja049378d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and L-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-α-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine. Copyright © 2004 American Chemical Society.

引用

页码：8622 / 8623

页数：2

共 30 条

[1]

Branco LC, 2002, CHEM-EUR J, V8, P3865, DOI 10.1002/1521-3765(20020902)8:17<3865::AID-CHEM3865>3.0.CO

[2]

2-L

[3]

Branco LC, 2002, ANGEW CHEM INT EDIT, V41, P2771, DOI 10.1002/1521-3773(20020802)41:15<2771::AID-ANIE2771>3.0.CO

[4]

2-U

[5] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTION OF ENANTIOMERS .2. ENZYME-CATALYZED ESTERIFICATIONS IN WATER ORGANIC-SOLVENT BIPHASIC SYSTEMS [J].

CHEN, CS ;

WU, SH ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (09) :2812-2817

[6] SYNTHESIS OF OPTICALLY-ACTIVE COMPOUNDS - A LARGE-SCALE PERSPECTIVE [J].

CROSBY, J .

TETRAHEDRON, 1991, 47 (27) :4789-4846

[7] Metal ion separations by supported liquid membranes [J].

de Gyves, J ;

de San Miguel, ER .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1999, 38 (06) :2182-2202

[8]

GOTO M, 1995, BIOTECHNOL TECH, V9, P101

[9] Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media [J].

Goto, M ;

Noda, S ;

Kamiya, N ;

Nakashio, F .

BIOTECHNOLOGY LETTERS, 1996, 18 (07) :839-844

[10]

GOTO M, 1995, J CHEM ENG JPN, V11, P893

← 1 2 3 →