Directional motility of kinesin motor proteins

被引:17
作者
Woehlke, G [1 ]
Schliwa, M [1 ]
机构
[1] Univ Munich, Adolf Butenandt Inst Cell Biol, D-80336 Munich, Germany
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2000年 / 1496卷 / 01期
关键词
molecular motor; kinesin; non-claret disjunctional protein; directionality; processivity; microtubule;
D O I
10.1016/S0167-4889(00)00013-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kinesin motor proteins are molecules capable of moving along microtubules. They share homology in the so-called core motor domain which acts as a microtubule-dependent ATPase. The surprising finding that different members of the superfamily move in opposite directions along microtubules despite their close similarity has stimulated intensive research on the determinants of motor directionality. This article reviews recent biophysical, biochemical, structural and mutagenic studies that contributed to the elucidation of the mechanisms that cause directional motion of kinesin motor proteins. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:117 / 127
页数:11
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