The radical scavenging effects of stilbene glucosides from Polygonum multiflorum

被引：103

作者：

Ryu, G

Ju, JH

Park, YJ

Ryu, SY

Choi, BW

Lee, BH

机构：

[1] Hanbat Natl Univ, Reg Res Ctr, Yusong Ku, Taejon 305719, South Korea

[2] Hanbat Natl Univ, Dept Chem Technol, Yusong Ku, Taejon 305719, South Korea

[3] Hanbat Natl Univ, INC, Yusung Ku, Taejon 305719, South Korea

[4] Korea Res Inst Chem Technol, Yusung Ku, Taejon 305600, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 05期

关键词：

stilbene glucoside; (E)-2,3,5,4,'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside; Polygonum multiflorum; DPPH radical scavenging activity;

D O I：

10.1007/BF02976935

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 muM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 muM).

引用

页码：636 / 639

页数：4

共 32 条

[1] 2-DIMENSIONAL SPECTROSCOPY - APPLICATION TO NUCLEAR MAGNETIC-RESONANCE [J].