Nucleophilic reactions between cyclic 1,2-sulfites and chloride ions

被引：7

作者：

Nymann, K ^{[1
]}

Jensen, L ^{[1
]}

Svendsen, JS ^{[1
]}

机构：

[1] UNIV TROMSO,INST MATH & PHYS SCI,DEPT CHEM,N-9037 TROMSO,NORWAY

来源：

ACTA CHEMICA SCANDINAVICA | 1996年 / 50卷 / 09期

关键词：

D O I：

10.3891/acta.chem.scand.50-0832

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When cyclic 1,2-sulfites are ring opened by chloride ion, the chlorohydrins are formed with low regio and stereo-selectivity. The mechanisms involved in the process were investigated by measuring the stereochemical outcome of the reactions. The results showed that reversible inversion pathways (S(N)2 reactions) and a retention pathway (S(N)2i reaction) gave rise to the loss in ee in both the chlorohydrins and in the cyclic 1,2-sulfites.

引用

页码：832 / 841

页数：10

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