Effect of Whole Body Hypothermia on Surfactant Function When Amniotic Fluid Is Meconium Stained

被引：11

作者：

Autilio, Chiara ^{[1
,2
]}

Echaide, Mercedes ^{[1
,2
]}

Dell'Orto, Valentina ^{[3
,4
]}

Perez-Gil, Jesus ^{[1
,2
]}

De Luca, Daniele ^{[3
,4
]}

机构：

[1] Univ Complutense Madrid, Fac Biol, Dept Biochem & Mol Biol, Madrid, Spain

[2] Univ Complutense Madrid, Hosp 12 Octubre, Res Inst, Madrid, Spain

[3] GHU Paris Sud, AP HP, Med Ctr A Beclere, Div Pediat & Neonatal Crit Care, Paris, France

[4] South Paris Univ, Paris, France

来源：

THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT | 2020年 / 10卷 / 03期

关键词：

cooling; surfactant; biophysics; neonate; meconium; ASPIRATION SYNDROME; PULMONARY SURFACTANT; LUNG SURFACTANT; INFLAMMATION; TEMPERATURE;

D O I：

10.1089/ther.2017.0012

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

We provide the first complete biophysical study of surfactant by captive bubble surfactometry from a neonate with meconium-stained amniotic fluid under controlled whole body hypothermia. Surfactant function improves after 48 hours of hypothermia, as surfactant cholesterol decreases. These findings partially explain positive effect of hypothermia on respiratory outcomes during meconium aspiration syndrome. A larger study including several neonates with or without lung disease is being conducted to better define the effect of hypothermia on surfactant function.

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收藏

页码：186 / 189

页数：4

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