Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters

被引：48

作者：

Zeevaart, JG

Parkinson, CJ ^{[1
]}

de Koning, CB

机构：

[1] CSIR Bio Chemtek, Special & Fine Chem Programme, ZA-1645 Modderfontein, South Africa

[2] Univ Witwatersrand, Sch Chem, Inst Mol Sci, ZA-2050 Wits, South Africa

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

palladium catalysis; enolate arylation; arylacetic acid esters;

D O I：

10.1016/j.tetlet.2004.04.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K3PO4 is described. The arylated acetoacetate ester is de-acylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：4261 / 4264

页数：4

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