PPAR-mediated activity of phthalates: A link to the obesity epidemic?

被引：263

作者：

Desvergne, Beatrice ^{[1
]}

Feige, Jerome N. ^{[1
]}

Casals-Casas, Cristina ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Integratif Genom, CH-1015 Lausanne, Switzerland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 304卷 / 1-2期

关键词：

Phthalates; Selective PPAR modulators; Metabolic disruptor; PROLIFERATOR-ACTIVATED RECEPTORS; PREGNANE-X-RECEPTOR; ENDOCRINE DISRUPTORS; NUCLEAR RECEPTORS; LIGAND-BINDING; ALPHA; GAMMA; TOXICITY; PROTEIN; MOUSE;

D O I：

10.1016/j.mce.2009.02.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endocrine disruption hypothesis asserts that exposure to small amounts of some chemicals in the environment may interfere with the endocrine system and lead to harmful effects in wildlife and humans. Many of these chemicals may interact with members of the nuclear receptor superfamily. Peroxisome proliferator-activated receptors (PPARs) are such candidate members, which interact with many different endogenous and exogenous lipophilic compounds. More particularly, the roles of PPARs in lipid and carbohydrate metabolism raise the question of their activation by a sub-class of pollutants, tentatively named "metabolic disrupters". Phthalates are abundant environmental micro-pollutants in Europe and North America and may belong to this class. Mono-ethyl-hexyl-phthalate (MEHP), a metabolite of the widespread plasticizer di-ethyl-hexyl-phthalate (DEHP), has been found in exposed organisms and interacts with all three PPARs. A thorough analysis of its interactions with PPAR gamma identified MEHP as a selective PPAR gamma modulator, and thus a possible contributor to the obesity epidemic. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 48

页数：6

共 51 条

[1] Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat [J].