Tacrolimus - A further update of its pharmacology and therapeutic use in the management of organ transplantation

被引:229
作者
Plosker, GL [1 ]
Foster, RH [1 ]
机构
[1] Adis Int Ltd, Auckland 10, New Zealand
关键词
tacrolimus; immunosuppressant; transplantation; pharmacodynamics; pharmacokinetics; drug interactions; therapeutic use; tolerability; pharmacoeconomics;
D O I
10.2165/00003495-200059020-00021
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tacrolimus (FK-506) is an immunosuppressant agent that acts by a variety of different mechanisms which include inhibition of calcineurin. It is used as a therapeutic alternative to cyclosporin, and therefore represents a cornerstone of immunosuppressive therapy in organ transplant recipients. Tacrolimus is now well established for primary immunosuppression in liver and kidney transplantation, and experience with its use in other types of solid organ transplantation, including heart, lung, pancreas and intestinal, as well as its use for the prevention of graft-versus-host disease in allogeneic bone marrow transplantation (BMT), is rapidly accumulating.
引用
收藏
页码:323 / 389
页数:67
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共 407 条
[1]  
Abd-Elghany W, 1998, BONE MARROW TRANSPL, V21, pS120
[2]   Successful prednisone withdrawal after living-related liver transplantation [J].
Abe, M ;
Fuchinoue, S ;
Koike, T ;
Sato, S ;
Uchida, Y ;
Murakami, T ;
Sageshima, J ;
Utumi, K ;
Ishii, Y ;
Kitajima, K ;
Yoshitake, O ;
Nakajima, I ;
Agishi, T .
TRANSPLANTATION PROCEEDINGS, 1998, 30 (04) :1441-1442
[3]  
ABOULJOUD MS, 1995, TRANSPLANT P, V27, P1121
[4]   The efficacy of Daclizumab for intestinal transplantation: Preliminary report [J].
Abu-Elmagd, K ;
McGhee, W ;
Martin, DD ;
Mazariegos, G ;
Fung, JJ ;
Strazl, TE ;
Reyes, J .
TRANSPLANTATION, 1999, 67 (09) :S588-S588
[5]   Evolution of clinical intestinal transplantation: Improved outcome and cost effectiveness [J].
Abu-Elmagd, KM ;
Reyes, J ;
Fung, JJ ;
Mazariegos, G ;
Bueno, J ;
Janov, C ;
Colangelo, J ;
Rao, A ;
Demetris, A ;
Starzl, TE .
TRANSPLANTATION PROCEEDINGS, 1999, 31 (1-2) :582-584
[6]   Peloisis hepatis due to Bartonella henselae in transplantation -: A hemato-hepato-renal syndrome [J].
Ahsan, N ;
Holman, MJ ;
Riley, TR ;
Abendroth, CS ;
Langhoff, EG ;
Yang, HC .
TRANSPLANTATION, 1998, 65 (07) :1000-1003
[7]   Biological activity of tacrolimus (FK506) and its metabolites from whole blood of kidney transplant patients [J].
Alak, AM ;
Moy, S .
TRANSPLANTATION PROCEEDINGS, 1997, 29 (05) :2487-2490
[8]   Conversion from tacrolimus to microemulsion formulation of cyclosporine in pediatric liver transplantation [J].
Alberti, D ;
Reding, R ;
Otte, JB ;
Falchetti, D ;
Rigamonti, W ;
Caccia, G ;
Sokal, E ;
de Goyet, JD .
TRANSPLANTATION PROCEEDINGS, 1998, 30 (05) :1858-1860
[9]   Antithrombotic effect of FK 506 versus cyclosporine in cardiac transplant recipients: Potential implications in transplant arteriopathy [J].
Alexis, JD ;
Freudenberger, RS ;
Kushwaha, SS ;
Fuster, V ;
Gass, AL ;
Badimon, JJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 31 (02) :207A-207A
[10]   Drug safety issues in pregnancy following transplantation and immunosuppression - Effects and outcomes [J].
Armenti, VT ;
Moritz, MJ ;
Davison, JM .
DRUG SAFETY, 1998, 19 (03) :219-232