Role of DNA polyrnerase IV in Escherichia coli SOS mutator activity

被引：31

作者：

Kuban, Wojciech

Banach-Orlowska, Magdalena

Schaaper, Roel M.

Jonczyk, Piotr

Fijalkowska, Iwona J.

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[2] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 22期

关键词：

POLYMERASE-III HOLOENZYME; POL-IV; ADAPTIVE MUTATION; LAGGING-STRAND; RECA PROTEIN; UNTARGETED MUTAGENESIS; GENETIC REQUIREMENTS; BASE SUBSTITUTION; FIDELITY; REPLICATION;

D O I：

10.1128/JB.01088-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product).

引用

页码：7977 / 7980

页数：4

共 46 条

[1] DNA polymerase II as a fidelity factor in chromosomal DNA synthesis in Escherichia coli [J].

Banach-Orlowska, M ;

Fijalkowska, IJ ;

Schaaper, RM ;

Jonczyk, P .

MOLECULAR MICROBIOLOGY, 2005, 58 (01) :61-70

[2] NATURE OF THE SOS MUTATOR ACTIVITY - GENETIC-CHARACTERIZATION OF UNTARGETED MUTAGENESIS IN ESCHERICHIA-COLI [J].

CAILLETFAUQUET, P ;

MAENHAUTMICHEL, G .

MOLECULAR & GENERAL GENETICS, 1988, 213 (2-3) :491-498

[3] PLASMID PKM101-MEDIATED MUTAGENESIS IN ESCHERICHIA-COLI IS INDUCIBLE [J].

CIESLA, Z .

MOLECULAR & GENERAL GENETICS, 1982, 186 (02) :298-300

[4] Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity [J].

Fijalkowska, IJ ;

Dunn, RL ;

Schaaper, RM .

JOURNAL OF BACTERIOLOGY, 1997, 179 (23) :7435-7445

[5] Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosome [J].

Fijalkowska, IJ ;

Jonczyk, P ;

Tkaczyk, MM ;

Bialoskorska, M ;

Schaaper, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10020-10025

[6] Adaptive mutation in Escherichia coli [J].

Foster, PL .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2000, 65 :21-29

[7] Asymmetry of frameshift mutagenesis during leading and lagging-strand replication in Escherichia coli [J].

Gawel, D ;

Jonczyk, P ;

Bialoskorska, M ;

Schaaper, RM ;

Fijalkowska, IJ .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2002, 501 (1-2) :129-136

[8] Error-prone repair DNA polymerases in prokaryotes and eukaryotes [J].

Goodman, MF .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :17-50

[9] A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates [J].

Jarosz, DF ;

Godoy, VG ;

Delaney, JC ;

Essigmann, JM ;

Walker, GC .

NATURE, 2006, 439 (7073) :225-228

[10] DNA-DAMAGING AGENTS STIMULATE GENE-EXPRESSION AT SPECIFIC LOCI IN ESCHERICHIA-COLI [J].

KENYON, CJ ;

WALKER, GC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05) :2819-2823

← 1 2 3 4 5 →