Depression and pesticide exposures in female spouses of licensed pesticide applicators in the agricultural health study cohort

Objective: This nested case-control study evaluated the association between depression and pesticide exposure among women. Methods: The study population included 29,074,female spouses of private pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Cases were women who had physician-diagnosed depression requiring medication. Lifetime pesticide use was categorized as never mixed/applied pesticides, low exposure (up to 225 days), high exposure (> 225 days), and a history of diagnosed pesticide poisoning. Results: After adjustment for state, age, race, off-farm work alcohol, cigarette smoking, physician visits, and solvent exposure, depression was significantly associated with a history of pesticide poisoning (odds ratio [OR] = 3.26; 95% confidence interval [G] = 1.72-619) but not low (OR = 1.09; CI = 0.91-1.31) or high (OR = 1.09; 95% CI = 0.91-1.31) cumulative pesticide exposure. Conclusion: Pesticide poisoning may contribute to risk of depression.