Exosomes: the future of biomarkers in medicine

被引：363

作者：

Properzi, Francesca ^{[1
]}

Logozzi, Mariantonia ^{[2
]}

Fais, Stefano ^{[2
]}

机构：

[1] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

[2] Natl Inst Hlth, Ist Super Sanita, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy

来源：

BIOMARKERS IN MEDICINE | 2013年 / 7卷 / 05期

关键词：

biomarkers; exosomes; nanotheranostics; nanovesicles; neurodegenerative diseases; prion diseases; tumor diagnosis; MEMBRANE-VESICLES; PRION PROTEIN; CEREBROSPINAL-FLUID; MIRNA SIGNATURE; ALPHA-SYNUCLEIN; TUMOR-GROWTH; HUMAN SALIVA; RELEASE; MICRORNAS; MICROVESICLES;

D O I：

10.2217/bmm.13.63

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes is a fingerprint of the releasing cell type and of its status. For this reason, and because they are released in easily accessible body fluids such as blood and urine, they represent a precious biomedical tool. A growing body of evidence suggests that exosomes may be used as biomarkers for the diagnosis and prognosis of malignant tumors. This article focuses on the exploitation of exosomes as diagnostic tools for human tumors and discusses possible applications of the same strategies to other pathologies, such as neurodegenerative diseases.

引用

页码：769 / 778

页数：10

共 87 条

[1]

Prion infections, blood and transfusions [J].

Aguzzi, Adriano ;

Glatzel, Markus .

NATURE CLINICAL PRACTICE NEUROLOGY, 2006, 2 (06) :321-329

[2]

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles [J].

Alais, Sandrine ;

Simoes, Sabrina ;

Baas, Dominique ;

Lehmann, Sylvain ;

Raposo, Graca ;

Darlix, Jean Luc ;

Leblanc, Pascal .

BIOLOGY OF THE CELL, 2008, 100 (10) :603-615

[3]

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[4]

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Schapira, Anthony H. ;

Gardiner, Chris ;

Sargent, Ian L. ;

Wood, Matthew J. A. ;

Cooper, J. Mark .

NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :360-367

[5]

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases [J].

Bala, Shashi ;

Petrasek, Jan ;

Mundkur, Shiv ;

Catalano, Donna ;

Levin, Ivan ;

Ward, Jeanine ;

Alao, Hawau ;

Kodys, Karen ;

Szabo, Gyongyi .

HEPATOLOGY, 2012, 56 (05) :1946-1957

[6]

Membrane Vesicles Released by Intestinal Epithelial Cells Infected with Rotavirus Inhibit T-Cell Function [J].

Barreto, Alfonso ;

Rodriguez, Luz-Stella ;

Lucia Rojas, Olga ;

Wolf, Marie ;

Greenberg, Harry B. ;

Franco, Manuel A. ;

Angel, Juana .

VIRAL IMMUNOLOGY, 2010, 23 (06) :595-608

[7]

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo [J].

Barron, Rona M. ;

Campbell, Susan L. ;

King, Declan ;

Bellon, Anne ;

Chapman, Karen E. ;

Williamson, R. Anthony ;

Manson, Jean C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (49) :35878-35886

[8]

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells [J].

Bellingham, Shayne A. ;

Coleman, Bradley M. ;

Hill, Andrew F. .

NUCLEIC ACIDS RESEARCH, 2012, 40 (21) :10937-10949

[9]

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses [J].

Bobrie, Angelique ;

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

TRAFFIC, 2011, 12 (12) :1659-1668

[10]

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection [J].

Castro-Seoane, Rocio ;

Hummerich, Holger ;

Sweeting, Trevor ;

Tattum, M. Howard ;

Linehan, Jacqueline M. ;

de Marco, Mar Fernandez ;

Brandner, Sebastian ;

Collinge, John ;

Kloehn, Peter-Christian .

PLOS PATHOGENS, 2012, 8 (02)

← 1 2 3 4 5 6 7 8 9 →