学术探索
学术期刊
新闻热点
数据分析
智能评审

Fulminant liver failure due to usnic acid for weight loss

被引：82
作者：
Durazo, FA
Lassman, C
Han, SHB
Saab, S
Lee, NP
Kawano, M
Saggi, B
Farmer, DG
Yersiz, H
Goldstein, RLI
Ghobrial, M
Busuttil, RW
机构：
[1] Univ Calif Los Angeles, Dumont Liver Transplant Ctr, Dept Surg, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Med, Div Digest Dis, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Pharmaceut Serv, Los Angeles, CA 90095 USA
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2004年 / 99卷 / 05期
关键词：
D O I：
10.1111/j.1572-0241.2004.04165.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The use of complementary and alternative medicine (CAM) in developed countries has increased significantly over the years. Among the most popular are the weight loss supplements or "fat burners." Liver failure due to these popular remedies has been widely recognized. Usnic acid has been an ingredient of dietary supplements that cause liver failure. Its hepatotoxicity has not been recognized because it is usually mixed with other ingredients that are presumably hepatotoxic. We describe a case of a 28-yr-old woman who presented with fulminant liver failure requiring orthotopic liver transplantation, after taking pure usnic acid for weight loss. This is the first report on fulminant liver failure associated with the ingestion of pure usnic acid. A discussion about hepatotoxicity of the different compounds of dietary supplements is presented. This is a reminder for the clinicians about the potential side effects of CAM.
引用
收藏
页码：950 / 952
页数：3
相关论文
共 18 条
[1]  
Abo-Khatwa A. N., 1996, Natural Toxins, V4, P96, DOI 10.1002/19960402NT7
[2]  
[Anonymous], 2002, Prepared Statement of John Diaz, 'Moody's Managing Director in United States Senate Committee on Governmental Affairs' in Rating the Raters: Enron and the Credit Rating Agencies
[3]  
Borum ML, 2001, AM J GASTROENTEROL, V96, P1654, DOI 10.1111/j.1572-0241.2001.03827.x
[4]   Antimitotic effects of usnic acid on different biological systems [J].
Cardarelli, M ;
Serino, G ;
Campanella, L ;
Ercole, P ;
Nardone, FD ;
Alesiani, O ;
Rossiello, F .
CELLULAR AND MOLECULAR LIFE SCIENCES, 1997, 53 (08) :667-672
[5]   Perceptions about complementary therapies relative to conventional therapies among adults who use both: Results from a national survey [J].
Eisenberg, DM ;
Kessler, RC ;
Van Rompay, MI ;
Kaptchuk, TJ ;
Wilkey, SA ;
Appel, S ;
Davis, RB .
ANNALS OF INTERNAL MEDICINE, 2001, 135 (05) :344-351
[6]   Severe hepatotoxicity associated with the dietary supplement LipoKinetix [J].
Favreau, JT ;
Ryu, ML ;
Braunstein, G ;
Orshansky, G ;
Park, SS ;
Coody, GL ;
Love, LA ;
Fong, TL .
ANNALS OF INTERNAL MEDICINE, 2002, 136 (08) :590-595
[7]   Biochemical and cellular mechanisms of toxic liver injury [J].
Kaplowitz, N .
SEMINARS IN LIVER DISEASE, 2002, 22 (02) :137-144
[8]   Long-term trends in the use of complementary and alternative medical therapies in the United States [J].
Kessler, RC ;
Davis, RB ;
Foster, DF ;
Van Rompay, MI ;
Walters, EE ;
Wilkey, SA ;
Kaptchuk, TJ ;
Eisenberg, DM .
ANNALS OF INTERNAL MEDICINE, 2001, 135 (04) :262-268
[9]  
Matsumaru K, 2002, HEPATOLOGY, V36, p480A
[10]  
Medwatch, 2003, FDA SAF INF ADV EV R
12