Uniparental disomy in cancer

被引：130

作者：

Tuna, Musaffe ^{[1
]}

Knuutila, Sakari ^{[2
,3
,4
]}

Mills, Gordon B. ^{[5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Genet, Houston, TX 77030 USA

[2] Univ Helsinki, Haartman Inst, Dept Pathol, FI-00014 Helsinki, Finland

[3] Univ Helsinki, HUSLAB, FI-00014 Helsinki, Finland

[4] Univ Helsinki, Cent Hosp, FI-00014 Helsinki, Finland

[5] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; NUCLEOTIDE POLYMORPHISM ANALYSIS; BECKWITH-WIEDEMANN-SYNDROME; TYROSINE KINASE JAK2; GENOME-WIDE ANALYSIS; COPY-NEUTRAL LOH; POLYCYTHEMIA-VERA; CHROMOSOME; 11P15; GENOTYPING MICROARRAYS; HETEROZYGOSITY;

D O I：

10.1016/j.molmed.2009.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.

引用

页码：120 / 128

页数：9

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