Diastereoselective Baylis-Hillman reactions: The design and synthesis of a novel camphor-based chiral auxiliary

被引:101
作者
Yang, KS [1 ]
Chen, KM [1 ]
机构
[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
关键词
D O I
10.1021/ol990315n
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of beta-hydroxy-alpha-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.
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页码:729 / 731
页数:3
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