Carbonic anhydrase inhibitors; Phosphoryl-sulfonamides - A new class of high affinity inhibitors of isozymes I and II

被引：13

作者：

Fenesan, I

Popescu, R

Scozzafava, A

Crucin, V

Mateiciuc, E

Bauer, R

Ilies, MA

Supuran, CT

机构：

[1] Univ Florence, Lab Chim Inorgan & Bioinorgan, I-50121 Florence, Italy

[2] Inst Chem Raluca Ripan, Lab Elementorgan Cpds, Cluj Napoca, Romania

[3] Univ Agr Sci & Vet Med, Fac Biotechnol, Dept Chem, Bucharest 71331, Romania

来源：

JOURNAL OF ENZYME INHIBITION | 2000年 / 15卷 / 03期

关键词：

carbonic anhydrase; isozymes I; II; phosphoryl sulfonamides; pK(a);

D O I：

10.3109/14756360009040690

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of phosphorylated aromatic:heterocyclic sulfonamides with the general formula ArSO2NHPO3H2 have been prepared by condensing ArSO2NH2 with phosphorus pentachloride, Followed by controlled hydrolysis in the presence of formic acid. The new derivatives generally act as stronger inhibitors of two carbonic anhydrase (CA) isozymes, CA I and CA II, as compared to the parent unsubstituted sulfonamides from which they were obtained. The inhibition mechanism by this new class of CA inhibitors, as well as structure activity correlations for the series of investigated derivatives, are also discussed.

引用

页码：297 / 310

页数：14

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