Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia

被引：36

作者：

Manschreck, TC

Redmond, DA

Candela, SF

Maher, BA

机构：

[1] Harvard Univ, Sch Med, Dept Psychiat, Lab Clin & Expt Psychopathol, Fall River, MA 02720 USA

[2] Brockton W Roxbury VA Hosp, Brockton, MA USA

[3] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1176/jnp.11.4.481

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study focused on the symptomatic and cognitive effects of the atypical antipsychotic clozapine in chronic hospitalized schizophrenia patients. Further, it explored how these effects might be related to discharge, an important functional outcome. Patients were assessed at baseline and at regular intervals with clinical instruments and a cognitive battery. Clozapine treatment produced symptomatic and cognitive improvements, positive changes that appeared to occur independently of one another. Baseline cognitive performance, as well as cognitive change with treatment, predicted discharge. Further investigation of the effects of clozapine and other atypical antipsychotics on cognition and functional outcome is warranted.

引用

页码：481 / 489

页数：9

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