Oxidative DNA cleavage by the antitumor antibiotic leinamycin and simple 1,2-dithiolan-3-one 1-oxides: Evidence for thiol-dependent conversion of molecular oxygen to DNA-cleaving oxygen radicals mediated by polysulfides

被引:87
作者
Mitra, K
Kim, W
Daniels, JS
Gates, KS
机构
[1] UNIV MISSOURI,DEPT CHEM,COLUMBIA,MO 65211
[2] UNIV MISSOURI,DEPT BIOCHEM,COLUMBIA,MO 65211
关键词
D O I
10.1021/ja971359z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:11691 / 11692
页数:2
相关论文
共 26 条
[1]   Thiol-mediated DNA alkylation by the novel antitumor antibiotic leinamycin [J].
Asai, A ;
Hara, M ;
Kakita, S ;
Kanda, Y ;
Yoshida, M ;
Saito, H ;
Saitoh, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) :6802-6803
[2]   1,2-Dithiolan-3-one 1-oxides: A class of thiol-activated DNA-Cleaving agents that are structurally related to the natural product leinamycin [J].
Behroozi, SJ ;
Kim, W ;
Dannaldson, J ;
Gates, KS .
BIOCHEMISTRY, 1996, 35 (06) :1768-1774
[3]   REACTION OF N-PROPANETHIOL WITH 3H-1,2-BENZODITHIOL-3-ONE 1-OXIDE AND 5,5-DIMETHYL-1,2-DITHIOLAN-3-ONE 1-OXIDE - STUDIES RELATED TO THE REACTION OF ANTITUMOR ANTIBIOTIC LEINAMYCIN WITH DNA [J].
BEHROOZI, SJ ;
KIM, WK ;
GATES, KS .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (13) :3964-3966
[4]   CRITICAL-REVIEW OF RATE CONSTANTS FOR REACTIONS OF HYDRATED ELECTRONS, HYDROGEN-ATOMS AND HYDROXYL RADICALS (.OH/.O-) IN AQUEOUS-SOLUTION [J].
BUXTON, GV ;
GREENSTOCK, CL ;
HELMAN, WP ;
ROSS, AB .
JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA, 1988, 17 (02) :513-886
[5]   SIRODESMINS A, B, C, AND G, ANTIVIRAL EPIPOLYTHIOPIPERAZINE-2,5-DIONES OF FUNGAL ORIGIN - X-RAY ANALYSIS OF SIRODESMIN-A DIACETATE [J].
CURTIS, PJ ;
GREATBANKS, D ;
HESP, B ;
CAMERON, AF ;
FREER, AA .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1977, (02) :180-189
[6]   VARACIN - A NOVEL BENZOPENTATHIEPIN FROM LISSOCLINUM-VAREAU THAT IS CYTOTOXIC TOWARD A HUMAN COLON-TUMOR [J].
DAVIDSON, BS ;
MOLINSKI, TF ;
BARROWS, LR ;
IRELAND, CM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (12) :4709-4710
[7]   OXIDATIVE DESTRUCTION OF DNA BY THE ADRIAMYCIN IRON COMPLEX [J].
ELIOT, H ;
GIANNI, L ;
MYERS, C .
BIOCHEMISTRY, 1984, 23 (05) :928-936
[8]   SYNTHESIS, CHARACTERIZATION, AND QUANTITATION OF THE MAJOR ADDUCTS FORMED BETWEEN SULFUR MUSTARD AND DNA OF CALF THYMUS AND HUMAN BLOOD [J].
FIDDER, A ;
MOES, GWH ;
SCHEFFER, AG ;
VANDERSCHANS, GP ;
BAAN, RA ;
DEJONG, LPA ;
BENSCHOP, HP .
CHEMICAL RESEARCH IN TOXICOLOGY, 1994, 7 (02) :199-204
[9]  
GANLEY B, UNPUB
[10]  
HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1