AID is required for c-myc/IgH chromosome translocations in vivo

被引：366

作者：

Ramiro, AR

Jankovic, M

Eisenreich, T

Difilippantonio, S

Chen-Kiang, S

Muramatsu, M

Hongo, T

Nussenzweig, A

Nussenzweig, MC

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

[3] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

[4] Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY 10021 USA

[5] Kyoto Univ, Grad Sch Med, Dept Med Chem, Kyoto 6068501, Japan

来源：

CELL | 2004年 / 118卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cell.2004.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Her a we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.

引用

页码：431 / 438

页数：8

共 59 条

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