Palladium-catalyzed Sonogashira and Hiyama reactions using phosphine-free hydrazone Ligands

被引：91

作者：

Mino, Takashi ^{[1
]}

Shirae, Yoshiaki ^{[1
]}

Saito, Takeshi ^{[1
]}

Sakamoto, Masami ^{[1
]}

Fujita, Tsutomu ^{[1
]}

机构：

[1] Chiba Univ, Dept Appl Chem & Biotechnol, Fac Engn, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 25期

关键词：

D O I：

10.1021/jo061734i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium/copper-catalyzed Sonogashira cross-coupling reaction of aryl halides with a variety of terminal alkynes under amine-free conditions in dimethylformamide (DMF) at 80 degrees C gave internal arylated alkynes using PdCl2(MeCN)(2) with phosphine-free hydrazone 2a as a ligand and CuI as the cocatalyst in good yields. We also found PdCl2/hydrazone ligand 1d in PhMe at 80 degrees C was a phosphine-free efficient catalyst system for a Hiyama cross-coupling reaction of aryl bromides with aryl(trialkoxy)silanes in good yields.

引用

页码：9499 / 9502

页数：4

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