Bronchial hyperreactivity and spirometric impairment in patients with seasonal allergic rhinitis

被引:41
作者
Ciprandi, G
Cirillo, I
Tosca, MA
Vizzaccaro, A
机构
[1] Osped San Martino Genova, Dipartimento Reg Testa Collo Padigl Specialita, I-16132 Genoa, Italy
[2] Navy Hosp, Dept Med, Ist Giannina Gaslini, Genoa, Italy
关键词
seasonal allergic rhinitis; bronchial hyperreactivity; methacholine challenge; FEF; 25-75;
D O I
10.1016/j.rmed.2004.02.021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We previously demonstrated in a group of patients with perennial allergic rhinitis alone, impairment of spirometric parameters and high percentage of bronchial hyperreactivity (BHR). Thus, the present study aimed at evaluating a group of subjects suffering from seasonal allergic rhinitis alone to investigate the presence of spirometric impairment and BHR both during and outside the pollen season. Methods: One-hundred rhinitics sensitized to pollen allergens only were evaluated during and outside the pollen season. Spirometry and methacholine bronchial challenge were performed. Results: Four rhinitics showed impaired values of FEV1 without referred symptoms of asthma during the pollen season. FEF 25-75 values were impaired in 17 rhinitics during the pollen season and in 11 rhinitics outside the pollen season (P < 0.05). Fifty-four patients showed positive methacholine bronchial challenge both during and outside the pollen season. PD20/FEV1 methacholine was lower during the pollen season than outside (P < 0.05). In BHR positive patients, reduced values of FVC (P < 0.05), FEV1 (P < 0.05), and FEF 25-75 (P < 0.01) were significantly demonstrated in comparison with BHR negative rhinitics. There was a relationship between BHR degree and FEF 25-75 values only during the pollen season (P < 0.001). Conclusions: This study evidences that an impairment of spirometric parameters may be observed also in patients with seasonal allergic rhinitis alone during the pollen season. A high percentage of these patients had BHR. A close relationship between upper and tower airways is confirmed also in the model of pollen allergy. Thus, a careful evaluation of lower airways should be performed also in those patients with seasonal allergic rhinitis alone. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:826 / 831
页数:6
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