Sticking with Synthetic Tissue Sealants

A recent report describes a new agent for the sealing and repair of tissues in animal models. This flowable, blood-resistant tissue glue is intended for use in surgical therapeutics. Tissue reanastomosis and wound closure are vital steps in surgery. Similarly, in percutaneous intervention, localized hemostasis is essential. Traditionally, sutures and staples have been used for tissue approximation and closure. Despite their basic efficacy, these tools have limitations that include the added trauma to tissue during placement and the difficulty of deployment in small spaces and tight geometries. Lang et al.(1) describe a new tool for tissue sealing and repair: a fluid, blood-resistant tissue glue for use in surgical and minimally invasive cardiovascular therapeutic procedures. This glue is a hydrophobic light-activated adhesive (HLAA) that consists of a biocompatible, biodegradable hydrophobic ...