The heart-liver metabolic axis: defective communication exacerbates disease

被引：31

作者：

Baskin, Kedryn K. ^{[1
]}

Bookout, Angie L. ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

EMBO MOLECULAR MEDICINE | 2014年 / 6卷 / 04期

关键词：

HYPERTROPHIC CARDIOMYOPATHY; GENE-MUTATIONS; FAT; ESTROGEN;

D O I：

10.1002/emmm.201303800

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The heart has been recognized as an endocrine organ for over 30years (de Bold, ); however, little is known about how the heart communicates with other organs in the body, and even less is known about this process in the diseased heart. In this issue of EMBO Molecular Medicine, Magida and Leinwand () introduce the concept that a primary genetic defect in the heart results in aberrant hepatic lipid metabolism, which consequently exacerbates hypertrophic cardiomyopathy (HCM). This study provides evidence in support of the hypothesis that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state.

引用

页码：436 / 438

页数：3

共 16 条

[1]

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? [J].

Bhatia, Lokpal S. ;

Curzen, Nicholas P. ;

Calder, Philip C. ;

Byrne, Christopher D. .

EUROPEAN HEART JOURNAL, 2012, 33 (10) :1190-+

[2]

G protein-coupled receptors for energy metabolites as new therapeutic targets [J].

Blad, Clara C. ;

Tang, Cong ;

Offermanns, Stefan .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (08) :603-619

[3]

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes [J].

Bordicchia, Marica ;

Liu, Dianxin ;

Amri, Ez-Zoubir ;

Ailhaud, Gerard ;

Dessi-Fulgheri, Paolo ;

Zhang, Chaoying ;

Takahashi, Nobuyuki ;

Sarzani, Riccardo ;

Collins, Sheila .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) :1022-1036

[4]

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice [J].

Bryzgalova, Galyna ;

Lundholm, Lovisa ;

Portwood, Neil ;

Gustafsson, Jan-Ake ;

Khan, Akhtar ;

Efendic, Suad ;

Dahlman-Wright, Karin .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (04) :E904-E912

[5]

Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy [J].

Crilley, JG ;

Boehm, EA ;

Blair, E ;

Rajagopalan, B ;

Blamire, AM ;

Styles, P ;

McKenna, WJ ;

Östman-Smith, I ;

Clarke, K ;

Watkins, H .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (10) :1776-1782

[6]

Estrogen regulation of adiposity and fuel partitioning - Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways [J].

D'Eon, TM ;

Souza, SC ;

Aronovitz, M ;

Obin, MS ;

Fried, SK ;

Greenberg, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (43) :35983-35991

[7]

de Bold AJ, 2011, CAN J PHYSIOL PHARM, V89, P527, DOI [10.1139/Y11-019, 10.1139/y11-019]

[8]

A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13 [J].

Grueter, Chad E. ;

van Rooij, Eva ;

Johnson, Brett A. ;

DeLeon, Susan M. ;

Sutherland, Lillian B. ;

Qi, Xiaoxia ;

Gautron, Laurent ;

Elmquist, Joel K. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

CELL, 2012, 149 (03) :671-683

[9]

A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use [J].

Liu, Sihao ;

Brown, Jonathan D. ;

Stanya, Kristopher J. ;

Homan, Edwin ;

Leidl, Mathias ;

Inouye, Karen ;

Bhargava, Prerna ;

Gangl, Matthew R. ;

Dai, Lingling ;

Hatano, Ben ;

Hotamisligil, Goekhan S. ;

Saghatelian, Alan ;

Plutzky, Jorge ;

Lee, Chih-Hao .

NATURE, 2013, 502 (7472) :550-+

[10]

Animal models of hypertrophic cardiomyopathy [J].

Maass, AH ;

Leinwand, LA .

CURRENT OPINION IN CARDIOLOGY, 2000, 15 (03) :189-196

← 1 2 →