Botulinum toxin type A (BOTOX) for treatment of migraine

被引:37
作者
Binder, WJ
Brin, MF
Blitzer, A
Pogoda, JM
机构
来源
DM DISEASE-A-MONTH | 2002年 / 48卷 / 05期
关键词
D O I
10.1053/mda.2002.24423
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An open-label study and 2 double-blind, placebo-controlled studies have provided supporting evidence of botulinum toxin type A (BTX-A) as an effective, well-tolerated treatment for migraine. Observed durations of benefit were consistent with known properties of BTX-A. Findings suggest that response may vary by features of preinjection headaches, such as migraine frequency. The precise mechanism by which BTX-A provides pain relief is hypothesized to be related not only to acetylcholine inhibition but also to a blocking action on the parasympathetic nervous system. Additional studies that control factors likely to be related to response may lead to better understanding of the BTX-A effect on migraine and an optimal treatment protocol.
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收藏
页码:323 / 335
页数:13
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