A novel signaling molecule for neuropeptide action: Activity-dependent neuroprotective protein

被引：53

作者：

Gozes, I ^{[1
]}

Bassan, M

Zamostiano, R

Pinhasov, A

Davidson, A

Giladi, E

Perl, O

Glazner, GW

Brenneman, DE

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel

[2] NICHD, Sect Dev & Mol Pharmacol, Dev Neurobiol Lab, NIH, Bethesda, MD 20892 USA

来源：

NEUROPEPTIDES: STRUCTURE AND FUNCTION IN BIOLOGY AND BEHAVIOR | 1999年 / 897卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb07884.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete coding sequence of a novel protein (828 amino acids, pi 5,99), a potential new mediator of vasoactive intestinal peptide (VIP) activity was recently revealed. The expression of this molecule, activity-dependent neuroprotective protein (ADNP), was augmented in the presence of VIP, in cerebral cortical astrocytes, The mRNA transcripts encoding ADNP mere enriched in the mouse hippocampus and cerebellum. The protein deduced sequence contained the following: (1) a unique peptide, NAPVSIPQ, sharing structural and immunological homologies with the previously reported, activity-dependent neurotrophic factor (ADNF) and exhibiting neuroprotection in vitro and in vivo; (2) a glutaredoxin active site; and (3) a classical zinc binding domain, Comparative studies suggested that the peptide, NAPVSIPQ (NAP), was more efficacious than peptides derived from ADNF, ADNP, a potential mediator of VIP-associated neuronal survival, and the new peptide, a potential lead compound for drug design, are discussed below.

引用

页码：125 / 135

页数：11

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