Gastrointestinal polyps and polyposis syndromes in children

被引:16
作者
Erdman, SH
Barnard, JA
机构
[1] Columbus Childrens Hosp, Columbus Childrens Res Inst, Div Gastroenterol, Columbus, OH USA
[2] Columbus Childrens Hosp, Columbus Childrens Res Inst, Div Mol Med, Columbus, OH USA
[3] Ohio State Univ, Columbus, OH 43210 USA
关键词
D O I
10.1097/00008480-200210000-00003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Gastrointestinal polyps are common during childhood and most often present with painless rectal bleeding. Most polyps occur as isolated colonic lesions and are not harbingers of an underlying genetic disorder, nor do they bestow a risk of gastrointestinal cancer. The astute pediatrician must be aware, however, that occasionally polyps may occur in the context of a genetic polyposis disorder characterized by an increase in the life-time risk of cancer in the gastrointestinal tract and other organ systems. This review outlines the major polyposis syndromes affecting children and highlights associated findings that might clue the alert physician to an underlying diagnosis. Recent developments in the understanding of the genetics of each disorder are emphasized. (C) 2002 Lippincott Williams Wilkins, Inc.
引用
收藏
页码:576 / 582
页数:7
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