Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation

被引：291

作者：

Kondo, Tomoo ^{[1
]}

Kishi, Mikiya ^{[1
]}

Fushimi, Takashi ^{[1
]}

Kaga, Takayuki ^{[1
]}

机构：

[1] Mizkan Grp Corp, Cent Res Inst, Aichi 4758585, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 13期

关键词：

Acetic acid; acetate; 5 '-AMP-activated protein kinase; peroxisome-proliferator-activated receptor alpha; body weight; body fat; fatty acid oxidation; ACTIVATED PROTEIN-KINASE; RECEPTOR-ALPHA; HEART-DISEASE; RISK-FACTORS; PPAR-ALPHA; GLUCOSE; RATS; ENERGY; VINEGAR; OBESITY;

D O I：

10.1021/jf900470c

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

We investigated the effect of acetic acid (AcOH) on the prevention of obesity in high-fat-fed mice. The mice were intragastrically administrated with water or 0.3 or 1.5% AcOH for 6 weeks. AcOH administration inhibited the accumulation of body fat and hepatic lipids without changing food consumption or skeletal muscle weight. Significant increases were observed in the expressions of genes for peroxisome-proliferator-activated receptor alpha (PPAR alpha) and for fatty-acid-oxidation- and thermogenesis-related proteins: acetyl-CoA oxidase (ACO), carnitine palmitoyl transferase-1 (CPT-1), and uncoupling protein-2 (UCP-2), in the liver of the AcOH-treatment groups. PPAR alpha, ACO, CPT-1, and UCP-2 gene expressions were increased in vitro by acetate addition to HepG2 cells. However, the effects were not observed in cells depleted of alpha 2 5 '-AMP-activated protein kinase (AMPK) by siRNA. In conclusion, AcOH suppresses accumulation of body fat and liver lipids by upregulation of genes for PPAR alpha and fatty-acid-oxidation-related proteins by alpha 2 AMPK mediation in the liver.

引用

页码：5982 / 5986

页数：5

共 27 条

[1]

Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α [J].