Metal fume fever: Characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value

被引:114
作者
Fine, JM
Gordon, T
Chen, LC
Kinney, P
Falcone, G
Beckett, WS
机构
[1] NYU,NELSON INST ENVIRONM MED,MED CTR,TUXEDO PK,NY 10987
[2] COLUMBIA UNIV,SCH PUBL HLTH,NEW YORK,NY
[3] YALE UNIV,SCH MED,OCCUPAT ENVIRONM MED PROGRAM,NEW HAVEN,CT 06520
[4] YALE UNIV,SCH MED,ENVIRONM HLTH SCI DIV,NEW HAVEN,CT 06520
关键词
D O I
10.1097/00043764-199708000-00006
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Results from animal and preliminary human exposure studies have called into question whether the 5 mg/m(3) 8-hour time-weighted average threshold limit value (TLV) for zinc oxide fume is sufficient to protect workers against metal fume fever. The objectives of this study were to determine the clinical effects of exposures to low concentrations of zinc oxide and to ascertain whether these exposures elevated circulating levels of specific cytokines, which could account for the symptoms of the metal fume fever syndrome. Thirteen resting naive subjects inhaled, on separate days, air and 2.5 and 5 mg/m(3) of furnace-generated zinc oxide fume for 2 hours. Subjects recorded symptoms and temperature and had blood drawn before and after each exposure. The mean (+/-SE) maximum rise in oral temperature at 6 to 12 hours after exposure was 1.4 +/- 0.3 degrees F after 5 mg/m(3), compared with 0.6 +/- 0.5 degrees F after air exposure (P < 0.05), Mean temperature was also elevated after exposure to 2.5 mg/m(3) zinc oxide (1.2 +/- 0.3 degrees). In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m(3) zinc oxide. Mean IL-6 values (pg/mL) at pre-exposure and at 3 and 6 hours post-exposure were 1.9 (+/-0.6), 2.8 (+/-0.7), and 2.9 (+/-0.6), respectively, on the air day and 1.6 (+/-0.6), 4.4 (+/-1.2), and 6.4 (+/-1.1) on the 5 mg/m(3) zinc oxide clay. Zinc oxide exposure did not significantly affect plasma levels of tumor necrosis factor. Total symptom scores peaked 9 hours after the 5 mg/m(3) zinc oxide exposure. Myalgias, cough, and fatigue were the predominant symptoms reported. Inhalation of zinc oxide for 2 hours at the current TLV of 5 mg/m(3) produces fever and symptoms along with elevation in plasma IL-6 levels.
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页码:722 / 726
页数:5
相关论文
共 21 条
  • [1] *AM C GOV IND HYG, 1991, DOC THRESH LIM VAL B, P1754
  • [2] AN EXPERIMENTAL HUMAN-MODEL OF METAL FUME FEVER
    BLANC, P
    WONG, H
    BERNSTEIN, MS
    BOUSHEY, HA
    [J]. ANNALS OF INTERNAL MEDICINE, 1991, 114 (11) : 930 - 936
  • [3] THE LUNG IN METAL FUME FEVER
    BLANC, P
    BOUSHEY, HA
    [J]. SEMINARS IN RESPIRATORY MEDICINE, 1993, 14 (03): : 212 - 225
  • [4] CYTOKINES IN METAL FUME FEVER
    BLANC, PD
    BOUSHEY, HA
    WONG, H
    WINTERMEYER, SF
    BERNSTEIN, MS
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (01): : 134 - 138
  • [5] RAT LUNG METALLOTHIONEIN AND HEME OXYGENASE GENE-EXPRESSION FOLLOWING OZONE AND ZINC-OXIDE EXPOSURE
    COSMA, G
    FULTON, H
    DEFEO, T
    GORDON, T
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 117 (01) : 75 - 80
  • [6] Dinarello CA, 1995, PRINCIPLES PRACTICE, P530
  • [7] DRINKER P, 1927, J IND HYG, V10, P331
  • [8] A trace element preparation containing zinc increases the production of interleukin-6 in human monocytes and glial cells
    Falus, A
    Beres, J
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 1996, 51 (03) : 293 - 301
  • [9] GORDON T, 1993, OCCUP MED, V8, P505
  • [10] PULMONARY EFFECTS OF INHALED ZINC-OXIDE IN HUMAN-SUBJECTS, GUINEA-PIGS, RATS, AND RABBITS
    GORDON, T
    CHEN, LC
    FINE, JM
    SCHLESINGER, RB
    SU, WY
    KIMMEL, TA
    AMDUR, MO
    [J]. AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL, 1992, 53 (08): : 503 - 509