Therapeutic interventions after spinal cord injury

被引：807

作者：

Thuret, Sandrine

Moon, Lawrence D. F.

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92109 USA

[2] Kings Coll London, Inst Psychiat, Ctr Cellular Basis Behav, MRC,Ctr Neurodegenerat Res, London SE5 8AF, England

[3] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 08期

关键词：

D O I：

10.1038/nrn1955

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have been tested in animal models. Many of these have reached, or are approaching, clinical trials. Here, we review these potential therapies, with an emphasis on the need for reproducible evidence of safety and efficacy. Individual therapies are unlikely to provide a panacea. Rather, we predict that combinations of strategies will lead to improvements in outcome after SCI. Basic scientific research should provide a rational basis for tailoring specific combinations of clinical therapies to different types of SCI.

引用

收藏

页码：628 / 643

页数：16

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