Pediatric stroke initiatives and preliminary studies: What is known and what is needed?

被引：31

作者：

Sofronas, Marianne

Ichord, Rebecca N.

Fullerton, Heather J.

Lynch, John K.

Massicotte, M. Patricia

Willan, Andrew R.

deVeber, Gabrielle

机构：

[1] Hosp Sick Children, Div Neurol, Toronto, ON M5G 1E2, Canada

[2] Hosp Sick Children, Dept Populat Hlth Sci, Toronto, ON M5G 1E2, Canada

[3] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[4] Univ Calif San Francisco, Div Neurol, San Francisco, CA 94143 USA

[5] NINDS, Bethesda, MD 20892 USA

[6] Stollery Childrens Hosp, Div Haematol Oncol, Edmonton, AB, Canada

[7] Univ Alberta, Edmonton, AB, Canada

[8] Univ Toronto, Toronto, ON, Canada

[9] Hosp Sick Children, Dept Populat Hlth Sci, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC NEUROLOGY | 2006年 / 34卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.pediatrneurol.2005.10.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebrovascular disorders are increasingly recognized as important causes of mortality and morbidity in the pediatric population. However, there have been no clinical trials performed to assess the safety and tolerability of acute interventions or secondary preventative treatments. In 2002, the International Pediatric Stroke Study was launched to create a network of investigators, with an interest in developing standards of practice, as well as design and implement the first-ever clinical trials in pediatric stroke. This article reviews existing studies in pediatric stroke epidemiology, risk factors, outcomes, as well as experience with antithrombotic trials in children. From there, current and future initiatives in the development of clinical trials in pediatric stroke are evaluated. (c) 2006 by Elsevier Inc. All rights reserved.

引用

页码：439 / 445

页数：7

共 23 条

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