Humanized immune system mouse models: progress, challenges and opportunities

被引：188

作者：

Allen, Todd M. ^{[1
]}

Brehm, Michael A. ^{[2
]}

Bridges, Sandra ^{[3
]}

Ferguson, Stacy ^{[4
]}

Kumar, Priti ^{[5
]}

Mirochnitchenko, Oleg ^{[6
]}

Palucka, Karolina ^{[7
]}

Pelanda, Roberta ^{[8
]}

Sanders-Beer, Brigitte ^{[3
]}

Shultz, Leonard D. ^{[9
]}

Su, Lishan ^{[10
]}

PrabhuDas, Mercy ^{[4
]}

机构：

[1] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA USA

[3] NIAID, Div AIDS, NIH, Rockville, MD USA

[4] NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD 20852 USA

[5] Yale Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT USA

[6] NIH, Off Res Infrastruct Programs, Div Program Coordinat Planning & Strateg Initiat, Off Director, Bldg 10, Bethesda, MD 20892 USA

[7] Jackson Lab, Farmington, CT USA

[8] Univ Colorado, Dept Immunol & Microbiol, Aurora, CO USA

[9] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA

[10] Univ N Carolina, Chapel Hill, NC 27515 USA

来源：

NATURE IMMUNOLOGY | 2019年 / 20卷 / 07期

关键词：

MICE; INFECTION; CELLS;

D O I：

10.1038/s41590-019-0416-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

On 18 December 2018, the National Institute of Allergy and Infectious Diseases convened a workshop entitled ‘Recent Advances and Opportunities in the Development and Use of Humanized Immune System Mouse Models’.

引用

页码：770 / 774

页数：5

共 21 条

[1]

The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer [J].

Carrillo, Mayra A. ;

Zhen, Anjie ;

Kitchen, Scott G. .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[2]

Modeling hepatitis B virus infection, immunopathology and therapy in mice [J].

Cheng, Liang ;

Li, Feng ;

Bility, Moses T. ;

Murphy, Christopher M. ;

Su, Lishan .

ANTIVIRAL RESEARCH, 2015, 121 :1-8

[3]

Mosquito Bite Delivery of Dengue Virus Enhances Immunogenicity and Pathogenesis in Humanized Mice [J].

Cox, Jonathan ;

Mota, Javier ;

Sukupolvi-Petty, Soila ;

Diamond, Michael S. ;

Rico-Hesse, Rebeca .

JOURNAL OF VIROLOGY, 2012, 86 (14) :7637-7649

[4]

Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice [J].

Dudek, Timothy E. ;

No, Daniel C. ;

Seung, Edward ;

Vrbanac, Vladimir D. ;

Fadda, Lena ;

Bhoumik, Priyasma ;

Boutwell, Christian L. ;

Power, Karen A. ;

Gladden, Adrianne D. ;

Battis, Laura ;

Mellors, Elizabeth F. ;

Tivey, Trevor R. ;

Gao, Xiaojiang ;

Altfeld, Marcus ;

Luster, Andrew D. ;

Tager, Andrew M. ;

Allen, Todd M. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (143)

[5]

Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver [J].

Dusseaux, Mathilde ;

Masse-Ranson, Guillemette ;

Darche, Sylvie ;

Ahodantin, James ;

Li, Yan ;

Fiquet, Oriane ;

Beaumont, Elodie ;

Moreau, Pierrick ;

Riviere, Lise ;

Neuveut, Christine ;

Soussan, Patrick ;

Roingeard, Philippe ;

Kremsdorf, Dina ;

Di Santo, James P. ;

Strick-Marchand, Helene .

GASTROENTEROLOGY, 2017, 153 (06) :1647-+

[6]

Humanized mice in infectious diseases [J].

Ernst, W. .

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2016, 49 :29-38

[7]

Humanized mice for HIV and AIDS research [J].

Garcia, J. Victor .

CURRENT OPINION IN VIROLOGY, 2016, 19 :56-64

[8]

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3 [J].

Goettel, Jeremy A. ;

Biswas, Subhabrata ;

Lexmond, Willem S. ;

Yeste, Ada ;

Passerini, Laura ;

Patel, Bonny ;

Yang, Siyoung ;

Sun, Jiusong ;

Ouahed, Jodie ;

Shouval, Dror S. ;

McCann, Katelyn J. ;

Horwitz, Bruce H. ;

Mathis, Diane ;

Milford, Edgar L. ;

Notarangelo, Luigi D. ;

Roncarolo, Maria-Grazia ;

Fiebiger, Edda ;

Marasco, Wayne A. ;

Bacchetta, Rosa ;

Quintana, Francisco J. ;

Pai, Sung-Yun ;

Klein, Christoph ;

Muise, Aleixo M. ;

Snapper, Scott B. .

BLOOD, 2015, 125 (25) :3886-3895

[9]

Humanized Mouse Models for Transplant Immunology [J].

Kenney, L. L. ;

Shultz, L. D. ;

Greiner, D. L. ;

Brehm, M. A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (02) :389-397

[10]

Receptor editing and genetic variability in human autoreactive B cells [J].

Lang, Julie ;

Ota, Takayuki ;

Kelly, Margot ;

Strauch, Pamela ;

Freed, Brian M. ;

Torres, Raul M. ;

Nemazee, David ;

Pelanda, Roberta .

JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (01) :93-108

← 1 2 3 →