Singlet oxygen conversion of indoles into α,β-unsaturated oxindoles in model compounds related to the welwitindolinone alkaloids

被引：28

作者：

Boissel, Valerie ^{[1
]}

Simpkins, Nigel S. ^{[1
]}

Bhalay, Gurdip ^{[2
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Horsham Res Ctr, Novartis Inst Biomed Res, Horsham RH12 5AB, W Sussex, England

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

基金：

英国工程与自然科学研究理事会;

关键词：

HAPALOSIPHON-FONTINALIS; WELWISTATIN; SKELETON; HAPALINDOLES; AUTOXIDATION; RESISTANCE;

D O I：

10.1016/j.tetlet.2009.02.061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of conformationally restricted bridged indoles, having structures related to the natural alkaloid N-methylwelwitindolinone C isothiocyanate (welwistatin), are oxidised to the corresponding alpha,beta-unsaturated oxindoles by treatment with singlet oxygen. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3283 / 3286

页数：4

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