Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs

被引：101

作者：

Hu, CP

Wedde-Beer, K

Auais, A

Rodriguez, MM

Piedimonte, G

机构：

[1] Univ Miami, Sch Med, Batchelor Childrens Res Inst, Pediat Pulm & Cyst Fibrosis Ctr,Dept Pediat, Miami, FL 33136 USA

[2] Univ Miami, Sch Med, Dept Med, Miami, FL 33136 USA

[3] Univ Miami, Sch Med, Dept Mol Cellular Pharmacol, Miami, FL 33136 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2002年 / 283卷 / 02期

关键词：

airway inflammation; asthma; bronchiolitis; neurotrophins; substance P;

D O I：

10.1152/ajplung.00414.2001

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1). We investigated whether the expression of NGF and its trkA and p75 receptors in the lungs is age dependent, whether it is upregulated during RSV infection, and whether it affects neurogenic inflammation. Pathogen-free rats were killed at 2 (weanling) to 12 (adult) wk of age; in addition, subgroups of rats were inoculated with RSV or virus-free medium. In pathogen-free rats, expression of NGF and its receptors in the lungs declined with age, but RSV doubled expression of NGF, trkA, and p75 in weanling and adult rats. Exogenous NGF upregulated NK1 receptor expression in the lungs. Anti-NGF antibody inhibited NK1 receptor upregulation and neurogenic inflammation in RSV-infected lungs. These data indicate that expression of NGF and its receptors in the lungs declines physiologically with age but is upregulated by RSV and is a major determinant of neurogenic inflammation.

引用

页码：L494 / L502

页数：9

共 36 条

[1]

[Anonymous], TXB PEDIAT INFECT DI

[2] Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma [J].

Bonini, S ;

Lambiase, A ;

Bonini, S ;

Angelucci, F ;

Magrini, L ;

Manni, L ;

Aloe, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :10955-10960

[3] Neurotrophins: A link between airway inflammation and airway smooth muscle contractility in asthma? [J].

Braun, A ;

Lommatzsch, M ;

Lewin, GR ;

Virchow, JC ;

Renz, H .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1999, 118 (2-4) :163-165

[4]

Braun A, 1998, EUR J IMMUNOL, V28, P3240, DOI 10.1002/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO

[5]

2-U

[6] HIGH-EFFICIENCY RECEPTOR-MEDIATED DELIVERY OF SMALL AND LARGE (48 KILOBASE GENE CONSTRUCTS USING THE ENDOSOME-DISRUPTION ACTIVITY OF DEFECTIVE OR CHEMICALLY INACTIVATED ADENOVIRUS PARTICLES [J].

COTTEN, M ;

WAGNER, E ;

ZATLOUKAL, K ;

PHILLIPS, S ;

CURIEL, DT ;

BIRNSTIEL, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :6094-6098

[7] Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs [J].

de Vries, A ;

Dessing, MC ;

Engels, F ;

Henricks, PAJ ;

Nijkamp, FP .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (05) :1541-1544

[8] EXPRESSION OF NERVE GROWTH-FACTOR AND NERVE GROWTH-FACTOR RECEPTOR TYROSINE KINASE TRK IN ACTIVATED CD4-POSITIVE T-CELL CLONES [J].

EHRHARD, PB ;

ERB, P ;

GRAUMANN, U ;

OTTEN, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :10984-10988

[9]

FOX AJ, 1998, AM J RESP CRIT CARE, V155, pA157

[10] Changes in the expression of the nerve growth factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased nerve growth factor plasma levels [J].

García-Suárez, O ;

Germanà, A ;

Hannestad, J ;

Pérez-Pérez, M ;

Esteban, I ;

Naves, FJ ;

Vega, JA .

CELL AND TISSUE RESEARCH, 2000, 301 (02) :225-234

← 1 2 3 4 →