Protected Peptide Nanoparticles: Experiments and Brownian Dynamics Simulations of the Energetics of Assembly

被引：40

作者：

Chen, Ting ^{[1
]}

D'Addio, Suzanne M. ^{[1
]}

Kennedy, Michael T. ^{[2
]}

Swietlow, Aleksander ^{[2
]}

Kevrekidis, Ioannis G. ^{[1
]}

Panagiotopoulos, Athanassios Z. ^{[1
]}

Prud'homme, Robert K. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA

[2] Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 06期

基金：

美国国家科学基金会;

关键词：

ORGANIC ACTIVES; COPOLYMERS; MIXER;

D O I：

10.1021/nl803205c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Soluble peptides, susceptible to degradation and clearance in therapeutic applications, have been formulated into protected nanoparticles for the first time through the process of kinetically controlled, block copolymer directed rapid precipitation using Flash NanoPrecipitation. Complementary Brownian dynamics simulations qualitatively model the nanoparticle formation process. The simulations corroborate the hypothesis that the size of nanoparticles decreases with increasing supersaturation. Additionally, the influence of the polymer-peptide interaction energy on the efficiency of nanoparticle protection by polymer surface coverage is elucidated in both experiments and simulations.

引用

页码：2218 / 2222

页数：5

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