共 23 条
Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction
被引:218
作者:

Mueller-Ehmsen, Jochen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Krausgrill, Benjamin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Burst, Volker
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Schenk, Kerstin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Neisen, Uta C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Fries, Jochen W. U.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Fleischmann, Bernd K.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Hescheler, Juergen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany

Schwinger, Robert H. G.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany
机构:
[1] Univ Cologne, Dept Internal Med 3, Lab Muscle Res & Mol Cardiol, D-50937 Cologne, Germany
[2] Univ Cologne, Dept Internal Med 4, D-50937 Cologne, Germany
[3] Univ Cologne, Inst Pathol, D-50937 Cologne, Germany
[4] Univ Bonn, Inst Physiol 1, D-5300 Bonn, Germany
[5] Univ Cologne, Inst Neurophysiol, D-50937 Cologne, Germany
关键词:
myocardial infarction;
cell therapy;
stem cells;
transplantation;
cell differentiation;
bone marrow cells;
mononuclear;
mesenchymal;
D O I:
10.1016/j.yjmcc.2006.07.023
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Bone marrow cells are used with promising results for cell therapy after myocardial infarction (MI). We determined the survival and organ distribution of transplanted mononuclear (MNC) or mesenchymal (MSC) bone marrow cells, and the influence of cell type, cell number and application time. MNC and MSC (male Fischer 344 rats) were injected into the border zone of MI (syngeneic females) immediately or 7 days after LAD ligation (10(5) or 10(6) cells, 50 mu l). After 0 h, 48 h, 5 days, 3 weeks and 6 weeks, DNA of heart, lung, liver, spleen, kidney, blood, bone marrow, brain and skeletal muscle was isolated and the number of donor cells determined by quantitative real-time PCR with Y-chromosome specific primers (each n >= 4). The percentage of donor-cells in the heart decreased rapidly from 34-80% of injected cells (0 h) to 0.3-3.5% (6 weeks) independent from cell type, number and application time. The absolute number increased after increasing injected cell number (106 VS. 105). In the lung, MNC and MSC were found at 0 h (126 48 and 140 3 per million organ cells), but in liver and kidney, only few. At 48 h and 6 weeks, an increasing number of MNC, but not MSC, were detected in the spleen (6 weeks, 602 +/- 173 per million organ cells vs. 95 50 in the heart, P = 0.02). In all other organs, only few or no grafted cells of either cell type were detected at these times. Organ distribution was independent from injection time. The low survival of grafted cells may limit their therapeutic impact, while their distribution to other organs must be considered in all cell therapy applications. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:876 / 884
页数:9
相关论文
共 23 条
[1]
Washout of transplanted cells from the heart: A potential new hurdle for cell transplantation therapy
[J].
Dow, J
;
Simkhovich, BZ
;
Kedes, L
;
Kloner, RA
.
CARDIOVASCULAR RESEARCH,
2005, 67 (02)
:301-307

Dow, J
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Simkhovich, BZ
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Kedes, L
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Kloner, RA
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA
[2]
A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction
[J].
Freyman, T
;
Polin, G
;
Osman, H
;
Crary, J
;
Lu, MM
;
Cheng, L
;
Palasis, M
;
Wilensky, RL
.
EUROPEAN HEART JOURNAL,
2006, 27 (09)
:1114-1122

Freyman, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Polin, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Osman, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Crary, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Lu, MM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Cheng, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Palasis, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA

Wilensky, RL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Hosp Univ Penn, Med Ctr, Div Cardiovasc, Philadelphia, PA 19104 USA
[3]
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
[J].
Gnecchi, M
;
He, HM
;
Liang, OD
;
Melo, LG
;
Morello, F
;
Mu, H
;
Noiseux, N
;
Zhang, LN
;
Pratt, RE
;
Ingwall, JS
;
Dzau, VJ
.
NATURE MEDICINE,
2005, 11 (04)
:367-368

Gnecchi, M
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

He, HM
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Liang, OD
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Melo, LG
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Morello, F
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Mu, H
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Noiseux, N
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Zhang, LN
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Pratt, RE
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Ingwall, JS
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

Dzau, VJ
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[4]
Monitoring of bone marrow cell homing into the infarcted human myocardium
[J].
Hofmann, M
;
Wollert, KC
;
Meyer, GP
;
Menke, A
;
Arseniev, L
;
Hertenstein, B
;
Ganser, A
;
Knapp, WH
;
Drexler, H
.
CIRCULATION,
2005, 111 (17)
:2198-2202

Hofmann, M
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Wollert, KC
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Meyer, GP
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Menke, A
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Arseniev, L
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Hertenstein, B
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Ganser, A
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Knapp, WH
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany

Drexler, H
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany
[5]
Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery - Implications for current clinical trials
[J].
Hou, DM
;
Youssef, EAS
;
Brinton, TJ
;
Zhang, P
;
Rogers, P
;
Price, ET
;
Yeung, AC
;
Johnstone, BH
;
Yock, PG
;
March, KL
.
CIRCULATION,
2005, 112 (09)
:I150-I156

Hou, DM
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Youssef, EAS
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Brinton, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Zhang, P
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Rogers, P
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Price, ET
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Yeung, AC
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Johnstone, BH
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

Yock, PG
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

March, KL
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Sch Med, Indianapolis, IN 46204 USA
[6]
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
[J].
Jackson, KA
;
Majka, SM
;
Wang, HG
;
Pocius, J
;
Hartley, CJ
;
Majesky, MW
;
Entman, ML
;
Michael, LH
;
Hirschi, KK
;
Goodell, MA
.
JOURNAL OF CLINICAL INVESTIGATION,
2001, 107 (11)
:1395-1402

Jackson, KA
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Majka, SM
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Wang, HG
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Pocius, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Hartley, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Majesky, MW
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Entman, ML
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Michael, LH
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Hirschi, KK
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Goodell, MA
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[7]
Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
[J].
Kajstura, J
;
Rota, M
;
Whang, B
;
Cascapera, S
;
Hosoda, T
;
Bearzi, C
;
Nurzynska, D
;
Kasahara, H
;
Zias, E
;
Bonafé, M
;
Nadal-Ginard, B
;
Torella, D
;
Nascimbene, A
;
Quaini, F
;
Urbanek, K
;
Leri, A
;
Anversa, P
.
CIRCULATION RESEARCH,
2005, 96 (01)
:127-137

Kajstura, J
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Rota, M
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Whang, B
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Cascapera, S
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Hosoda, T
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Bearzi, C
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Nurzynska, D
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Kasahara, H
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Zias, E
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Bonafé, M
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Nadal-Ginard, B
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Torella, D
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Nascimbene, A
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Quaini, F
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Urbanek, K
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Leri, A
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

Anversa, P
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA
[8]
Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
[J].
Kinnaird, T
;
Stabile, E
;
Burnett, MS
;
Shou, M
;
Lee, CW
;
Barr, S
;
Fuchs, S
;
Epstein, SE
.
CIRCULATION,
2004, 109 (12)
:1543-1549

Kinnaird, T
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Stabile, E
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Burnett, MS
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Shou, M
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Lee, CW
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Barr, S
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Fuchs, S
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA

Epstein, SE
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA Washington Hosp Ctr, Inst Cardiovasc Res, Washington, DC 20010 USA
[9]
Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury
[J].
Li, RK
;
Mickle, DAG
;
Weisel, RD
;
Rao, VV
;
Jia, ZQ
.
ANNALS OF THORACIC SURGERY,
2001, 72 (06)
:1957-1963

Li, RK
论文数: 0 引用数: 0
h-index: 0
机构: Toronto Gen Hosp, Res Inst, Div Cardiac Surg, Toronto, ON M5G 2C4, Canada

Mickle, DAG
论文数: 0 引用数: 0
h-index: 0
机构: Toronto Gen Hosp, Res Inst, Div Cardiac Surg, Toronto, ON M5G 2C4, Canada

Weisel, RD
论文数: 0 引用数: 0
h-index: 0
机构: Toronto Gen Hosp, Res Inst, Div Cardiac Surg, Toronto, ON M5G 2C4, Canada

Rao, VV
论文数: 0 引用数: 0
h-index: 0
机构: Toronto Gen Hosp, Res Inst, Div Cardiac Surg, Toronto, ON M5G 2C4, Canada

Jia, ZQ
论文数: 0 引用数: 0
h-index: 0
机构: Toronto Gen Hosp, Res Inst, Div Cardiac Surg, Toronto, ON M5G 2C4, Canada
[10]
Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment
[J].
Limbourg, FP
;
Ringes-Lichtenberg, S
;
Schaefer, A
;
Jacoby, C
;
Mehraem, Y
;
Jäger, MD
;
Limbourg, A
;
Fuchs, M
;
Klein, G
;
Ballmaier, M
;
Schlitt, HJ
;
Schrader, J
;
Hilfiker-Kleiner, D
;
Drexler, H
.
EUROPEAN JOURNAL OF HEART FAILURE,
2005, 7 (05)
:722-729

Limbourg, FP
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Ringes-Lichtenberg, S
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Schaefer, A
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Jacoby, C
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Mehraem, Y
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Jäger, MD
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Limbourg, A
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Fuchs, M
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Klein, G
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Ballmaier, M
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Schlitt, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Schrader, J
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Hilfiker-Kleiner, D
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany

Drexler, H
论文数: 0 引用数: 0
h-index: 0
机构: Hannover Med Sch, Dept Cardiol & Angiol, D-30625 Hannover, Germany