Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment

被引：9

作者：

Giardino, L

Zanni, M

Bettelli, C

Savina, MA

Calza, L

机构：

[1] UNIV MILAN,INST OTOLARYNGOL 2,MILAN,ITALY

[2] UNIV MODENA,DEPT PSYCHOSENSORY PATHOL,I-41100 MODENA,ITALY

[3] PATHOPHYSIOL CTR NERVOUS SYST,MODENA,ITALY

[4] PFIZER ITALIANA,ROME,ITALY

[5] UNIV CAGLIARI,INST HUMAN PHYSIOL,CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 312卷 / 02期

关键词：

sertraline; glutamic acid decarboxylase mRNA; hybridization; in situ; brain;

D O I：

10.1016/0014-2999(96)00588-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-aminobutyric acid transmission in the anxiolytic effect of sertraline is discussed.

引用

页码：183 / 187

页数：5

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