Biodistribution of anti-CEA F(ab')(2) fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma

被引：1

作者：

Buchegger, F ^{[1
]}

Gillet, M ^{[1
]}

Doenz, F ^{[1
]}

Vogel, CA ^{[1
]}

Achtari, C ^{[1
]}

Mach, JP ^{[1
]}

Delaloye, B ^{[1
]}

Delaloye, AB ^{[1
]}

机构：

[1] CHU VAUDOIS,DIV NUCL MED,CH-1011 LAUSANNE,SWITZERLAND

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1996年 / 17卷 / 06期

关键词：

D O I：

10.1097/00006231-199606000-00008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')(2) fragment was studied in three patients with Liver metastases from colorectal cancer. Identical MAb fragments, labelled with either I-125 or I-131 were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')(2) fragments gives no measurable advantage over more convenient injections into a peripheral vein.

引用

页码：500 / 503

页数：4