In this paper, 10 years of time-variable gravity data from the Gravity Recovery and Climate Experiment Release 05 have been used to evaluate the glacier melting rate in high-mountain Asia (HMA) using a new computing scheme, i.e., the Space Domain Inverse method. We find that in HMA area, there are three different kinds of signal sources that should be treated together. The two generally accepted sources, glacier melting and India underground water depletion, are estimated to change at the rate of -35.0 +/- 5.8 Gt/yr (0.09 mm/yr sea level rising) and -30.6 +/- 5.0 Gt/yr, respectively. The third source is the remarkable positive signal (+30 Gt/yr) in the inner Tibetan Plateau, which is challenging to explain. Further, we have found that there is a 5 year undulation in Pamir and Karakoram, which can explain the controversies of the previous studies on the glacier melting rate here. This 5 year signal can be explained by the influence of Arctic Oscillation and El Nino-Southern Oscillation.