Synthesis of a cis-conformationally restricted peptide bond isostere and its application to the inhibition of the HIV-1 protease

被引：59

作者：

Abell, AD

Foulds, GJ

机构：

[1] Department of Chemistry, University of Canterbury, Christchurch

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 17期

关键词：

D O I：

10.1039/a702458d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylamine peptide bond isostere is reported, This has been used to produce a new class of HIV-1 protease inhibitor.

引用

页码：2475 / 2482

页数：8

共 27 条

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