Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk

被引：22

作者：

Becquart, Pierre ^{[1
]}

Petitjean, Gael

Al Tabaa, Yassine

Valea, Diane

Huguet, Marie-France

Tuaillon, Edouard

Meda, Nicolas

Vendrell, Jean-Pierre

Van de Perre, Philippe

机构：

[1] Inst Res & Dev, Res Unit 145, UMR 145, Montpellier, France

[2] Univ Montpellier I, F-34006 Montpellier, France

[3] Montpellier Univ Hosp, Lab Bacteriol Virol, Montpellier, France

[4] Ctr MURAZ, Dept HIV AIDS & Reprod Hlth, Bobo Dioulasso, Burkina Faso

来源：

AIDS | 2006年 / 20卷 / 10期

关键词：

D O I：

10.1097/01.aids.0000233581.64467.55

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In breast milk and paired blood samples of nine HIV-1-infected lactating women, we undertook a study to detect a CD4 T-cell reservoir and to investigate its capacity to enter viral production after activation. Breast milk-infected CD4 T cells have a greater capacity to produce viral particles actively than blood CD4 T cells. This observation may explain the apparent paradox of a transmissible viral infection from a body fluid with a low viral concentration.

引用

页码：1453 / 1455

页数：3

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