No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese

被引：94

作者：

Hamajima, N

Matsuo, K

Suzuki, T

Nakamura, T

Matsuura, A

Hatooka, S

Shinoda, M

Kodera, Y

Yamamura, Y

Hirai, T

Kato, T

Tajima, K

机构：

[1] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan

[2] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi 4648681, Japan

[3] Aichi Canc Ctr Hosp, Dept Surg, Nagoya, Aichi 4648681, Japan

来源：

CANCER LETTERS | 2002年 / 181卷 / 01期

关键词：

p73 dinucleotide polymorphism; p53 Arg72Pro polymorphism; esophageal cancer risks; stomach cancer risk; colorectal cancer risk; polymerase chain reaction with confronting two-pair primers;

D O I：

10.1016/S0304-3835(02)00041-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4TI4 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or case, as a whole. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 85

页数：5

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