Plasma brain natriuretic peptide concentrations in patients undergoing pulmonary vein isolation

被引：28

作者：

Date, T. ^{[1
]}

Yamane, T. ^{[1
]}

Inada, K. ^{[1
]}

Matsuo, S. ^{[1
]}

Miyanaga, S. ^{[1
]}

Sugimoto, K. ^{[1
]}

Shibayama, K. ^{[1
]}

Taniguchi, I. ^{[1
]}

Mochizuki, S. ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Div Cardiol, Dept Internal Med,Minato Ku, Tokyo 1058461, Japan

来源：

HEART | 2006年 / 92卷 / 11期

关键词：

D O I：

10.1136/hrt.2005.083022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To examine whether raised plasma brain natriuretic peptide (BNP) concentrations decrease after successful pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). Methods: 53 patients ( mean age 53 years) with drug-refractory, paroxysmal lone AF underwent segmental ostial PVI. Blood samples were collected before and after PVI. BNP concentrations were determined by immunoassays. Results: Median plasma BNP concentrations were significantly higher in patients with lone AF than in controls (patients with supraventricular tachyarrhythmias, n = 21) (64.6 (71.9) v 13.9 (7.8) pg/ml, p < 0.01). AF recurred in 21 patients after the initial PVI procedure ( recurrent AF group), and the others were free from AF without antiarrhythmic drugs (non-recurrent AF group). BNP concentrations were significantly decreased by PVI in the non-recurrent AF group (38.9 (39.1) to 18.3 (16.1) pg/ml, p < 0.01) but not in the recurrent AF group. Conclusions: Raised plasma BNP concentrations decreased after successful segmental ostial PVI in patients with AF.

引用

页码：1623 / 1627

页数：5

共 25 条

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