Mechanism of puberty

被引：12

作者：

Brook, CGD

机构：

[1] Middlesex Hosp, Endocrine Unit, London W1N 8AA, England

[2] Great Ormond St Hosp Children, London Ctr Paediat Endocrinol, London WC1N 3JH, England

来源：

HORMONE RESEARCH | 1999年 / 51卷

关键词：

puberty; hypothalamo-pituitary-gonadal axis;

D O I：

10.1159/000053162

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypothalamo-pituitary-gonadal axis in children is fully functional in fetal life and immediately after birth. The reason why it declines with advancing years of childhood is not clear but gonadotropin pulsatility is at a nadir at 6 years of age. From that time pulsatile gonadotropin starts to reappear but, again, the reason why this happens is completely unknown. All of the events of puberty can be ascribed to pulsatile gonadotropin-releasing hormone stimulation causing pulsatile gonadotropin stimulation of sex steroids. The sex steroids explain the development of the pubertal characteristics; the fact that girls have an earlier growth spurt than boys is explained by the differential effect of oestradiol and testosterone on hypothalamic control of pituitary growth hormone secretion. Copyright (C) 1999 S. Karger AG, Basel.

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收藏

页码：52 / 54

页数：3

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