Endocytosis of lipid rafts: an identity crisis

被引：61

作者：

Sharma, P ^{[1
]}

Sabharanjak, S ^{[1
]}

Mayor, S ^{[1
]}

机构：

[1] Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 03期

基金：

英国惠康基金;

关键词：

detergent-resistant membranes; GPI-anchored proteins; lipids; membrane traffic; sorting;

D O I：

10.1016/S1084-9521(02)00049-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Membrane rafts enriched in cholesterol and sphingolipids have been hypothesized to be keg mediators of sorting and signaling Junctions of associated molecules. Apart from a limited number of biophysical studies in living cell membranes, raft-association has been defined by a simple biochemical criterion, namely the ability to partition with detergent-resistant membranes (DRMs). Here we examine the evidence for the specification of internalization mechanisms and endocytic pathways by rafts as defined by this criterion. We have surveyed the endocytic trafficking of a variety of molecules such as lipids, toxins, glycosylphosphatidylinositol (GPI)-anchored proteins, and DRM-associated transmembrane proteins.

引用

页码：205 / 214

页数：10

共 93 条

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