Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses by Aspergillus fumigatus

被引：81

作者：

Chai, Louis Y. A. ^{[1
,3
,4
]}

Kullberg, Bart Jan ^{[1
,3
]}

Vonk, Alieke G. ^{[5
]}

Warris, Adilia ^{[2
,3
]}

Cambi, Alessandra ^{[6
]}

Latge, Jean-Paul ^{[7
]}

Joosten, Leo A. B. ^{[1
,3
]}

van der Meer, Jos W. M. ^{[1
,3
]}

Netea, Mihai G. ^{[1
,3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6525 GA Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Pediat, NL-6525 GA Nijmegen, Netherlands

[3] Nijmegen Inst Infect Inflammat & Immun N4i, NL-6525 GA Nijmegen, Netherlands

[4] Natl Univ Singapore Hosp, Dept Med, Singapore 119074, Singapore

[5] Univ Med Ctr Rotterdam, Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3015 CE Rotterdam, Netherlands

[6] Radboud Univ Nijmegen, Dept Tumour Immunol, Nijmegen Ctr Mol Life Sci, NL-6525 GA Nijmegen, Netherlands

[7] Inst Pasteur, Unite Aspergillus, F-75015 Paris, France

来源：

INFECTION AND IMMUNITY | 2009年 / 77卷 / 05期

基金：

英国医学研究理事会;

关键词：

BETA-GLUCAN RECEPTOR; MANNOSE RECEPTOR; CANDIDA-ALBICANS; HOST-DEFENSE; MURINE MACROPHAGES; DENDRITIC CELLS; INVASIVE ASPERGILLOSIS; CYTOKINE PRODUCTION; IMMUNE RECOGNITION; HUMAN MONOCYTES;

D O I：

10.1128/IAI.01455-08

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1 beta proinflammatory responses in human mononuclear cells with suppression of IL-1 beta mRNA transcription. Background TLR2 and TLR4 mRNA transcription was not influenced. A. fumigatus conidia induced TLR2 internalization and uptake into the phagosome with a resultant decrease in surface receptor expression. A. fumigatus hyphae, on the other hand, selectively downregulated the TLR4-mediated response. These novel immunosuppressive effects may facilitate the invasiveness of A. fumigatus.

引用

页码：2184 / 2192

页数：9

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