Cross metathesis of the amino acid homoallylglycine

被引:38
作者
Gibson, SE
Gibson, VC
Keen, SP
机构
关键词
D O I
10.1039/a702027i
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Reaction of various protected forms of the amino acid homoallylglycine with aryl- and alkyl-substituted alkenes in the presence of 5 mol% Cl-2(PCy3)(2)Ru=CHPh gives cross metathesis products in acceptable synthetic yield (43-66%).
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页码:1107 / 1108
页数:2
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共 37 条
  • [1] BALDWIN JE, 1992, J CHEM RES-S, P173
  • [2] Alkene metathesis in the synthesis of novel beta-lactams
    Barrett, AGM
    Baugh, SPD
    Gibson, VC
    Giles, MR
    Marshall, EL
    Procopiou, PA
    [J]. CHEMICAL COMMUNICATIONS, 1996, (19) : 2231 - 2232
  • [3] Tandem asymmetric allylboration-alkene metathesis: A novel strategy for the synthesis of trans-disubstituted homoallylic alcohols
    Barrett, AGM
    Beall, JC
    Gibson, VC
    Giles, MR
    Walker, GLP
    [J]. CHEMICAL COMMUNICATIONS, 1996, (19) : 2229 - 2230
  • [4] Studies toward a synthesis of epothilone A: Stereocontrolled assembly of the acyl region and models for macrocyclization
    Bertinato, P
    Sorensen, EJ
    Meng, DF
    Danishefsky, SJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) : 8000 - 8001
  • [5] THE FIRST SYNTHESIS OF THE ABCD RING-SYSTEM OF MANZAMINE-A - CONSTRUCTION OF THE MACROCYCLIC RING-D
    BORER, BC
    DEERENBERG, S
    BIERAUGEL, H
    PANDIT, UK
    [J]. TETRAHEDRON LETTERS, 1994, 35 (19) : 3191 - 3194
  • [6] Clark JS, 1997, TETRAHEDRON LETT, V38, P127
  • [7] Clark JS, 1997, TETRAHEDRON LETT, V38, P123
  • [8] SUPRAMOLECULAR DESIGN BY COVALENT CAPTURE - DESIGN OF A PEPTIDE CYLINDER VIA HYDROGEN-BOND-PROMOTED INTERMOLECULAR OLEFIN METATHESIS
    CLARK, TD
    GHADIRI, MR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (49) : 12364 - 12365
  • [9] AMINO-ACID DERIVED HOMOCHIRAL POLYMERS VIA RING-OPENING METATHESIS POLYMERIZATION
    COLES, MP
    GIBSON, VC
    MAZZARIOL, L
    NORTH, M
    TEASDALE, WG
    WILLIAMS, CM
    ZAMUNER, D
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (21) : 2505 - 2506
  • [10] Preparation of allylsilanes via cross-metathesis
    Crowe, WE
    Goldberg, DR
    Zhang, ZJ
    [J]. TETRAHEDRON LETTERS, 1996, 37 (13) : 2117 - 2120