Nitrile hydrolases

被引：186

作者：

Kobayashi, M ^{[1
]}

Shimizu, S ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(99)00058-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of nitrile-related enzymes have been screened over the past year for use in synthetic applications. There have also been significant advances in our understanding of the structures and modes of regulation of metal-containing nitrile hydratases. Enzyme structural characterization has provided new insights into how the molecular structure determines the enzyme function and how an enzyme can be endowed with new: properties. This information has important implications for potential future applications other than the present industrial production of acrylamide and nicotinamide.

引用

页码：95 / 102

页数：8

共 47 条

[1] Z-phenylacetaldoxime degradation by a novel aldoxime dehydratase from Bacillus sp. strain OxB-1
Asano, Y
Kato, Y
[J]. FEMS MICROBIOLOGY LETTERS, 1998, 158 (02) : 185 - 190
[2] A NEW ENZYME NITRILE HYDRATASE WHICH DEGRADES ACETONITRILE IN COMBINATION WITH AMIDASE
ASANO, Y
TANI, Y
YAMADA, H
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1980, 44 (09): : 2251 - 2252
[3] Cloning of three A-type cytochromes p450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome p450 in the biosynthesis of the cyanogenic glucoside dhurrin
Bak, S
Kahn, RA
Nielsen, HL
Moller, BL
Halkier, BA
[J]. PLANT MOLECULAR BIOLOGY, 1998, 36 (03) : 393 - 405
[4] Transcriptional analysis of the nitrile-degrading operon from Rhodococcus sp ACV2 and high level production of recombinant amidase with an Escherichia coli-T7 expression system
Bigey, F
Chebrou, H
Fournand, D
Arnaud, A
[J]. JOURNAL OF APPLIED MICROBIOLOGY, 1999, 86 (05) : 752 - 760
[5] Highly efficient control of iron-containing nitrile hydratases by stoichiometric amounts of nitric oxide and light
Bonnet, D
Artaud, I
Moali, C
Petre, D
Mansuy, D
[J]. FEBS LETTERS, 1997, 409 (02) : 216 - 220
[6] DEHYDRATION OF ALKYLALDOXIME AND ARYLALDOXIME AS A NEW CYTOCHROME-P450 CATALYZED REACTION - MECHANISM AND STEREOCHEMICAL CHARACTERISTICS
BOUCHER, JL
DELAFORGE, M
MANSUY, D
[J]. BIOCHEMISTRY, 1994, 33 (25) : 7811 - 7818
[7] Conn EE, 1981, CYANIDE BIOL, P183
[8] Molecular characterisation of a novel thermophilic nitrile hydratase
Cramp, RA
Cowan, DA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1999, 1431 (01): : 249 - 260
[9] Engineering nitrile hydratase activity into a cysteine protease by a single mutation
Dufour, E
Storer, AC
Menard, R
[J]. BIOCHEMISTRY, 1995, 34 (50) : 16382 - 16388
[10] Duran R, 1998, J BASIC MICROB, V38, P101, DOI 10.1002/(SICI)1521-4028(199805)38:2<101::AID-JOBM101>3.3.CO

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