Inhibition of cell cycle progression on HepG2 cells by hypsiziprenol A9, isolated from Hypsizigus marmoreus

被引：35

作者：

Chang, JS

Son, JK

Li, G

Oh, EJ

Kim, JY

Park, SH

Bae, JT

Kim, HJ

Lee, IS

Kim, OM

Kozukue, N

Han, JS

Hirose, M

Lee, KR ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Food & Nutr, Kyongsan 712749, South Korea

[2] Yeungnam Univ, Coll Pharm, Gyongsan, South Korea

[3] Asia Univ, Gyongsan 712220, South Korea

[4] Keimyung Univ, Ctr Tradit Microorgan Resources, Taegu, South Korea

[5] Taekyeung Coll, Dept Hotel Cooker, Gyonsan, South Korea

[6] Yeungnam Univ, Dept Home Management, Kyongsan 712749, South Korea

来源：

CANCER LETTERS | 2004年 / 212卷 / 01期

关键词：

hypsiziprenol A9; Hypsizigus marmoreus; retinoblastoma protein; cell cycle arrest; cyclin D1; cyclin E;

D O I：

10.1016/j.canlet.2004.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antiproliferative activities of fractions of Hypsizigus marmoreus were examined using HepG2 cells in vitro. The methanol extract of H. marmoreus markedly induced antiproliferative activity, and an active compound from this mushroom was identified as hypsiziprenol A(9). Hypsiziprenol A(9) inhibited cell proliferation in a time- and concentration-dependent manner by up to 80% on HepG2 cells by inducing arrest of the G1 phase. Further investigation revealed that hypsiziprenol A(9) decreased expression of phosphorylated retinoblastoma protein (ppRb), cyclin D1, and cyclin E in a dose-dependent manner. These results suggest that hypsiziprenol A(9) can inhibit the growth of HepG2 cells through inducing G1 phase cell cycle arrest due to the inhibition of pRb phosphorylation. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：7 / 14

页数：8

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