The molecular control of renal branching morphogenesis: current knowledge and emerging insights

被引：62

作者：

Piscione, TD ^{[1
]}

Rosenblum, ND ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Program Dev Biol, Div Nephrol, Toronto, ON M5G 1X8, Canada

来源：

DIFFERENTIATION | 2002年 / 70卷 / 06期

基金：

加拿大健康研究院;

关键词：

kidney development; branching morphogenesis; collecting duct;

D O I：

10.1046/j.1432-0436.2002.700602.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian kidney development requires the formation of a patterned, branched network of collecting ducts, a process termed renal branching morphogenesis. Disruption of renal branching morphogenesis during human kidney development results in renal dysplasia, the major cause of renal failure in young children. Genetic evidence, combined with in vitro data, have implicated transcription factors, secreted growth factors, and cell surface signaling peptides as critical regulators of renal branching morphogenesis. This review discusses the current knowledge regarding the regulation of renal branching morphogenesis in vivo provided by the analysis of genetic mutations in mice and humans which disrupt collecting duct system development. In addition, in vivo and in vitro evidence regarding the functions of several other gene families are considered, rendering new insight into emerging regulatory roles for these molecules in renal branching morphogenesis.

引用

页码：227 / 246

页数：20

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